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Reliability, Validity and Responsiveness of the EQ-5D-5L in Assessing and Valuing Health Status in Adolescents and Young Adults with Posttraumatic Stress Disorder : a Randomized Controlled Trail


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Dams, Judith ; Rimane, Eline ; Steil, Regina ; Renneberg, Babette ; Rosner, Rita ; König, Hans-Helmut:
Reliability, Validity and Responsiveness of the EQ-5D-5L in Assessing and Valuing Health Status in Adolescents and Young Adults with Posttraumatic Stress Disorder : a Randomized Controlled Trail.
In: Psychiatric quarterly. 92 (2021) 2. - S. 459-471.
ISSN 0033-2720 ; 1573-6709



To validate the EQ-5D-5L health-related quality of life (HrQoL) questionnaire inadolescents and young adults with posttraumatic stress disorder (PTSD) after sexualand/or physical abuse. We used data from a randomized controlled trial of 87participants with PTSD aged 14–21 years. The discriminative ability was evaluatedby comparing participants scores on thedescriptive system of the EQ-5D-5L withgeneral population scores. Furthermore, the discriminative ability between sub-groups of participants with different disease severity levels was estimated. Corre-lations between the EQ-5D index and clinical parameters were used to measureconstruct validity. Test-retest reliability was measured by intraclass correlationcoefficients (ICC) between baseline, posttreatment and 3-month follow-up scoresof participants with stable symptoms. Finally, the responsiveness of the EQ-5D wascalculated by mean differences, effect sizes and receiver operating characteristic(ROC) analyses for participants with improved symptoms. Participants reportedsignificantly more problems on the dimensions“mobility”,“usual activities”,“pain/discomfort”and“anxiety/depression”than the general population. The EQ-5D-5L was able to discriminate between different disease severity levels. The EQ-5D index and clinical scales were significantly correlated with absolute values ofcorrelation coefficients varying between 0.21 and 0.59. Furthermore, ICCs between 0.65 and 0.91 indicated good test-retest reliability for the EQ-5D index. The ICCs for the EQ-VAS between baseline and 3-month follow-up, and posttreatment and 3-month follow-up were statistically significant with 0.71 and 0.87, respectively,whereas the ICC between baseline and posttreatment was 0.08 and not statistically significant. Effect sizes to measure the responsiveness ranged between −0.008 and 0.40 for the EQ-5D index and −0.32 and 0.40 for the EQ-VAS. Furthermore, the area under the curve in ROC analyses was between 0.40 and 0.64 for the EQ-5Dindex and 0.60 and 0.70 for the EQ-VAS. Discriminative ability, test-retest reli-ability and construct validity of the EQ-5D-5L were good, whereas the responsive-ness was rather weak. Nevertheless, the EQ-5D-5L can be used to measure HrQoLin adolescents and young adults with PTSD. German Clinical Trials Registeridentifier: DRKS00004787; dateof registration: 18th March 2013;

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Schlagwörter:Reliability, Validity, Responsiveness, EQ5D, Posttraumatic stress disorder
Sprache des Eintrags:Englisch
Institutionen der Universität:Philosophisch-Pädagogische Fakultät > Psychologie > Lehrstuhl für Klinische und Biologische Psychologie
DOI / URN / ID:10.1007/s11126-020-09814-6
Open Access: Freie Zugänglichkeit des Volltexts?:Ja
Verlag:Kluwer Academic / Human Sciences Press
Die Zeitschrift ist nachgewiesen in:
Titel an der KU entstanden:Nein
Eingestellt am: 23. Jun 2021 13:07
Letzte Änderung: 26. Okt 2021 11:23
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